Ariana Vrykolakis is a young woman working as a freelance artist who happens to be half-vampire. Her father Antonis Vrykolakis and his brother Grigoris are vampires who descend from the evil Vrykolakis family. They tried to blend in with society until they reconnect with an old acquaintance named James Ryder who invites the two brothers to join his clan.
James happens to be longtime enemies with with Deacon Thompson, the leader of the vampire hunters. As the new leader of the vampire clan, James promotes hatred and fear of Deacon to rile up the vampires. Meanwhile, Ariana and her mother start to get pressured by Antonis to become vampires after him and his brother join the clan.
Ariana becomes frustrated and hopeless until she meets a handsome vampire hunter, Lukas Vasilias. They instantly form a connection and soon Ariana learns that she was destined to be a vampire hunter herself.
Lukas teaches Ariana the ways of vampire hunting even though she doesn't think she is qualified. Later Ariana and Lukas must embark on dangerous missions to free innocent people from vampires and save Lukas' father.